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KMID : 0377619650080060657
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Korean Jungang Medical Journal
1965 Volume.8 No. 6 p.657 ~ p.679
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Experimental Studies on the Effect of the Temperatures upon the Hepatic Cell Mitosis of the Adult Albino Rats.
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Abstract
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In order to observe the effect of, the temperatures upon the hepatic cell mitosis, albino rats weighing from 120 gm, to 150 gm were kept in an incubator at the temperature of 32 °C, or in a refrigerator at the temperature of minus 10 °C for a certain period respectively, and than hepatic cell mitosis was timely observed. In another hand, a small amount of serum of the albino rats which have been exposed in the above two temperatures was injected into unexposed normal albino rats, and the effect of injected sera upon the hepatic cell rnitosis also was observed? And the following conclusions were obtained.
1) In the group of the albino rats which were exposed in the temperature of .30°C, for a certain period, their hepatic cell mitosis has shown the rapid increase in it´s activity since 4 houter after exposure, and thereafter reached in 12 hours the maximum level which is five to six times of that in the unexposed group, 24 hours later it returned to the normal level due to the gradual decrease in it´s activity, However, the continuous decrease of hepatic cell mitosis reaches the minimum level in 48 to 72 hours and returned again to the normal level.
2) In the group of the albino rats which were exposured in the temperature of minus 10°C for a certain period, the hepatic cell mitosis also has shown the relatively rapid increase in it´s activity since 4 to 8 hours after exposure and reached the maximum level in 18 hours, which is more than two times of the unexposed, "Thereafter the hepatic cell mitosis decreased in it´s activity relatively repidly in ´one fourth of the normal level in 48 to 72 hours, And a tendency returning to the normal level in one week due to gradual decrease in mitotic activity was also observed.
3) In the group injected with the serum of the albino rats exposed in the temperature of 32°C, for a certain period, the hepatic cell mitosis seemed to slightly decreased in it´s activity immediately after the injection. However, thereafter it showed the rapid increase in it´s activity reaching the maximum level in 8 to 12 hours, which is about two times of that in the uninjected, And then the relatively rapid decrease in mitotic activity was shown and it became about me third .of that in the uninjected in 24 hours, and returned to the normal level due to the gradual: decrease thereafter.
4) In the group injected with the serum of the albino rats exposed in the temperature of minus 10°C for a certain period, a tendency of more. or less slight decrease of the hepatic cell mitosis was shown immediately after the injection. And the hepatic cell mitosis reached the maximum level in 12, hours which is. about two times of that in the uninjected due to the rapid increase in it´s, activity. However, in. 48 hours later it became far -less active than the normal. and thereafter by gradual increase restored to the normal level again.
5) Therefore, it may be suggested that the temperature of 32°C. and animus 10°C have possibly an effect upon the hepatic cell mitosis of albino rats, which at first: stimulated, thereafter slightly inhibited, and finally restored to the normal condition.
And it is also suggested that the sera of albino rats exposed in the above temperatures have possibly an effect upon the hepatic cell mitosis which, at first more or less is inhibited and followed by the rapid increase in it´s activity thereafter, And then it showed the relatively rapid decrease in activity and finally returned to the normal condition.
It seems likely that there may possibly be two factors both stimulating and inhibiting the hepatic cell mitosis in the sera of the albino rats exposed in the above mentioned temperatures.
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